Understanding Metabolic Regulation
We investigate how cells sense and respond to metabolic changes, with implications for human health and disease.
Nutrient Sensing & Metabolism
Our lab investigates how cells sense and respond to nutrient availability, focusing on metabolic signaling pathways that regulate cellular fate decisions. We use genetic, biochemical, and computational approaches to understand how metabolic dysfunction contributes to disease.
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Metabolic Flux Analysis
- Quantifying metabolic pathway activity in living cells
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Proteomics
- Mapping protein modifications that regulate metabolism
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Disease Models
- Studying metabolic dysfunction in disease contexts
Computational Approaches to Metabolism
We develop and apply computational methods to analyze complex metabolic networks, integrate multi-omics data, and identify novel therapeutic targets. Our computational platform accelerates discovery by predicting metabolic vulnerabilities in disease.
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Metabolite Profiling
- Comprehensive analysis of cellular metabolomes
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Epigenetic Regulation
- How metabolism influences gene expression
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Cell Fate Decisions
- Metabolic control of differentiation and proliferation
Our Techniques & Approaches
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Multi-omics Integration
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Combining genomics, proteomics, and metabolomics data
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Metabolic Flux Analysis
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Isotope tracing to map metabolic pathways
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Computational Biology
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Machine learning for metabolic network analysis