Kristin is an Assistant Research Professor in the Department of Pharmacology and Cancer Biology, and a Faculty Member of the Sarah W. Stedman Nutrition and Metabolism Center at Duke University Medical Center.
She earned a Bachelors of Science at the University of Kentucky and a Ph.D. in Biochemistry and Biophysics at the University of North Carolina at Chapel Hill with Gerhard Meissner. She was a post-doctoral fellow with Tony Means at Duke University where she studied Ca2+-calmodulin protein kinase signaling pathways in T cells. Following her post-doctoral work she continued with Tony Means as Assistant Research Professor, discovering a role for CaM kinase kinase 2 as an AMPK kinase in the hypothalamus that regulates expression of the potent appetite enhancer, NPY. Her work demonstrated that deletion or inhibition of CaM kinase kinase 2 in the mouse reduces food intake and protects the animals from high-fat diet-induced obesity, glucose intolerance, and insulin resistance. She is an expert in biochemistry, metabolic regulation, cellular function and mouse physiology, and identified direct regulatory roles for CaM kinase kinase 2 in carbohydrate and fat metabolism in liver, demonstrating that liver-specific deletion of the kinase lowers blood glucose and improves whole body glucose tolerance in the mouse.
With extensive experience in the field of protein post-translational modification biology, she is now interested in how acetylation and other post-translational modifications integrate biological signals.