Darren joined the Duke Molecular Physiology Institute (DMPI) in 2015 as an Associate in Research in the Hirschey Lab. He holds a B.S. in Biochemistry and an M.S. in Toxicology from N.C. State University. Darren comes to DMPI with 20+ years of pharmaceutical research experience in early stage drug discovery. His experience is primarily with in vitro systems using recombinant proteins and cultured cells to identify small molecule leads against biological targets to treat various diseases, including metabolic and musculoskeletal. He has extensive experience with multiple enzyme classes and has developed and performed assays to assist medicinal chemists in developing structure-activity relationships for new chemical entities, including mechanism of action studies. He also led multidisciplinary teams working to discover drug candidates. A highlight of his career is being on the team that discovered Avodart® for the treatment of benign prostatic hyperplasia.